Acts 28:3-6:
And when Paul had gathered a bundle of sticks, and laid them on the fire, there came a viper out of the heat, and fastened on his hand.
And when the barbarians saw the venomous beast hang on his hand, they said among themselves, No doubt this man is a murderer, whom, though he hath escaped the sea, vengeance suffereth not to live.
And shook off the beast into the fire, and felt no harm.
Howbeit they looked when he should have swollen, or fallen down dead suddenly: but after they had looked a great while, and saw no harm come to him, they changed their minds, and said that he was a god.
Notes on Acts 28:3-6:
Paul did not deliberately handle a snake; the snake fastened onto Paul. This was an example of what Jesus meant about taking up serpents. There are no biblical examples of deliberately picking up snakes. That dangerous practice, done by certain “snake-handling cults,” should never be done. Although the Greek word used for take up does mean what it appears to mean at face value, there is no biblical evidence that this is a voluntary thing as opposed to what Paul did when he threw the poisonous snake into the fire.
See also:
Notes on Mark 16:15-18
Healing and Deliverance from Poisoning
Objection: Mark 16:9-20 Was Not in Some Early Manuscripts
Objection: Not All of “Those Who Believe” Will Pick Up Snakes, So Not All of “Those Who Believe” Are Supposed to Lay Hands on the Sick and Have Them Recover (Mark 16:17-18)
Condition: Snakebites