Genesis 26:34-35:

And Esau was forty years old when he took to wife Judith the daughter of Beeri the Hittite, and Bashemath the daughter of Elon the Hittite:
Which were a grief of mind unto Isaac and to Rebekah.

See also:

Objection: Isaiah DID Refer to Actual Physical and Mental Illnesses and Distresses, but Not Necessarily to a Vicarious Bearing of Them, but to Sympathetic Bearing of the Troubles of This Life